Terms you need to know about central control of blood pressure
Renin-angiotensin-aldosterone pathway or RAA pathway |
The pathway outlined below, which begins with the kidneys detecting low blood flow and ends with aldosterone’s causing the kidneys to reabsorb Na+ and water into the blood and bring blood volume back up to normal. |
Renin |
The compound secreted by the kidneys when they don’t get enough blood |
Angiotensinogen |
Means ‘angiotensin maker’ – a compound already in the bloodstream, which reacts with renin to form angiotensin I |
Angiotensin I |
Means ‘blood vessel tightener’. A weak vasoconstrictor. |
Angiotensin converting enzyme or ACE |
An enzyme found in the lungs. Converts angiotensin I to angiotensin II. This enzyme is targeted by some anti-hypertensive drugs, the ACE inhibitors |
Angiotensin II |
A stronger vasoconstrictor. It also stimulates the production of Aldosterone |
Adrenal cortex |
The outer layer of the adrenal gland |
Aldosterone |
A hormone produced by the adrenal cortex when it detects angiotensin II in the blood. This hormone causes the kidneys to turn on their Na+/K+ ATPase, and they then pump 3 Na+ from the urine into the blood and 2K+ from the blood into the urine. Water follows the majority of ions, so water also enters the blood, raising the blood volume. |
|
|
Vasomotor center |
A group of neurons in the medulla oblongata that causes blood vessels to constrict or dilate in order to keep blood pressure stable |
Antidiuretic hormone or ADH |
Means ‘against urination.’ A hormone secreted when blood pressure is low. It causes the kidneys to reabsorb water into the blood, increasing blood volume. This reduces the production of urine. |
baroreceptors |
Cells in the carotids and aorta which measure stretch in the vessel walls to tell how high the blood pressure is. |
Atrial natriuretic hormone (or factor or peptide) |
Secreted by the atria when they are over-stretched. It causes the person to lose Na+ and water in the urine, reducing blood volume |
B-type natriuretic hormone (or factor or peptide) |
Secreted by the ventricles when they are over-stretched. It causes the person to lose Na+ and water in the urine, reducing blood volume |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|